Keywords
Categories
Abstract
Background: Canna tuber (Canna Indica L.) is a plant that contains large amounts of carbohydrates, so it can be used as a starch producer. Canna starch is starch extracted from canna tubers can be used to diluent. Objective: to determine the effect of the combination of green canna tuber starch with Avicel Ph 101 as a filler for ibuprofen tablets on the physical form of tablets and to determine the optimum formulation of the combination of canna tuber starch. with avicel PH 101. Method: This study is an experimental research using a descriptive method. The samples in this study were formulations combining canna tuber starch and Avicel PH 101 as fillers in directly compressed ibuprofen tablets, using the Simplex Lattice Design (SLD) method. Results: The physical quality test of the tablets from the 5 formulas met the requirements for the uniformity test of tablet weight, tablet size uniformity test formulas, tablet hardness test, friability test, and the dissolution test of the 5 formulas meets the requirements within 60 minutes of dissolving not less than 85% of the amount indicated on the label. Conclusions: The formulation of Ibuprofen tablets with Avicel PH 101 as a filler combined with canna tuber starch can affect the physical quality. The optimum formula for ibuprofen tablets combined with canna tuber starch and Avicel PH 101 is the proportion of canna tuber starch as much as 50,000 mg and Avicel PH 101 as much as 50,000 mg, with a desirabilty value of 1,000.